Publications by authors named "Johannes Constantin Schittny"
Article Synopsis
- Chronic obstructive pulmonary disease (COPD) is a leading cause of death globally and may be triggered by both genetic and environmental factors, particularly early life nicotine exposure, which this study examines in relation to lung health and emphysema in adulthood.
- A two-hit model was used: mouse pups were exposed to nicotine in utero and during lactation, followed by elastase treatment at 11 weeks, with researchers measuring lung function and analyzing molecular changes over time.
- The study found that nicotine exposure did not adversely affect lung function compared to controls, but elastase treatment caused significant lung damage, inflammation, and alterations in lung mechanics, indicating the complex interplay between early life exposures and adult lung health.
Mechanical ventilation (MV) is life-saving but potentially harmful for lungs of premature infants. So far, animal models dealt with the acute impact of MV on immature lungs, but less with its delayed effects. We used a newborn rodent model including non-surgical and therefore reversible intubation with moderate ventilation and hypothesized that there might be distinct gene expression patterns after a ventilation-free recovery period compared to acute effects directly after MV.
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