The influence of micrometastases on prognosis and survival in stage I-II colon cancer patients: the Enroute⊕ Study.

Background: The presence of lymph node metastases remains the most reliable prognostic predictor and the gold indicator for adjuvant treatment in colon cancer (CC). In spite of a potentially curative resection, 20 to 30% of CC patients testing negative for lymph node metastases (i.e.