Publications by authors named "Johannes C C M In't Veen"
Article Synopsis
- Dupilumab is an effective treatment for moderate-to-severe atopic dermatitis (AD) and severe asthma (SA), but there hasn't been much real-world analysis on its adverse events, particularly those related to the eyes (DAOSD).
- This study analyzed data from patients with AD and SA receiving dupilumab to compare the prevalence of adverse events, focusing on ocular problems and treatment discontinuation rates.
- Results showed a higher prevalence of ocular adverse events in AD patients (62.1%), while SA patients experienced more headaches and injection site reactions, underlining the need for physician awareness when prescribing dupilumab to AD patients and emphasizing the effectiveness of ophthalmic treatments for managing eye-related issues.
Adherence to single inhaler triple therapy and digital inhalers in Chronic Obstructive Pulmonary Disease: a literature review and protocol for a randomized controlled trial (TRICOLON study).
Liz J A Cuperus Job van der Palen Arnoud Aldenkamp Astrid van Huisstede Erik W M A Bischoff Johannes C C M In 't Veen
BMC Pulm Med
July 2024
Article Synopsis
- Medication non-adherence in COPD patients is a pressing issue, prompting interest in simpler treatment options like single-inhaler triple therapy (SITT) over multi-inhaler triple therapy (MITT) and the use of smart inhalers.
- A literature review examining adherence levels between SITT and MITT found that most observational trials favored SITT for better adherence and clinical outcomes, while smart inhalers generally showed a positive but varied impact.
- The TRICOLON trial is a planned study to further investigate the effectiveness of SITT and smart inhalers on improving adherence among COPD patients, involving 300 participants across ten hospitals.
Article Synopsis
- Symptoms of asthma and COPD can be similar, and patients may have both conditions simultaneously, indicating a need for better assessment tools.
- The study aimed to develop a new questionnaire by combining the asthma control questionnaire (ACQ) and the clinical COPD questionnaire (CCQ) to evaluate disease burden across all obstructive lung diseases.
- Using data from various patient cohorts, researchers identified nine key questions through Principal Component Analysis (PCA), leading to the proposed "Obstructive Lung Disease Questionnaire" for more effective disease assessment.
Article Synopsis
- The study investigates the differences in innate lymphoid cell (ILC) populations, specifically ILC1s and ILC2s, between patients with COPD (Chronic Obstructive Pulmonary Disease), asthma, and control groups.
- Results show significantly higher levels of inflammatory CD4 ILC1s and lower levels of CD117 ILC2s in COPD patients compared to asthma patients, highlighting distinct inflammatory profiles.
- These findings could help in understanding the mechanisms of COPD and asthma, potentially aiding in better patient classification and treatment strategies.
Article Synopsis
- The study aimed to evaluate a personalized diagnostic pathway for patients with Chronic Obstructive Pulmonary Disease (COPD) or Asthma in a real-world outpatient setting.
- The results revealed that only 35% of patients attended all scheduled appointments after the pathway's implementation, with factors like logistical complexity and low socioeconomic status contributing to dropouts.
- Despite the challenges, the study showed a significant increase in the creation of personalized care plans and diagnostic documentation, indicating that holistic care planning can be effectively implemented, but improvements are needed to increase patient participation.
Introduction: Interstitial lung disease (ILD) may be difficult to distinguish from other respiratory diseases due to overlapping clinical presentation. Recognition of ILD is often late, causing delay which has been associated with worse clinical outcome. Electronic nose (eNose) sensor technology profiles volatile organic compounds in exhaled breath and has potential to detect ILD non-invasively.
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- Patients with Chronic Obstructive Pulmonary Disease (COPD) are at a higher risk for developing lung cancer, but there are currently no reliable biomarkers to detect it early, making new detection methods essential.
- A study called BreathCloud utilized eNose technology to analyze exhaled breath in patients with COPD to see if it could identify early signs of lung cancer over a two-year period.
- Results showed that distinct breath profiles from patients with COPD could effectively differentiate those who later developed lung cancer, achieving high accuracy in predictions (receiver operating characteristic curve values of 0.89 and 0.86).
Article Synopsis
- The study investigates the relationship between clustering analyses of COPD and the GOLD ABCD classification, focusing on whether new behavioral factors influence clustering outcomes.
- It found that while certain clusters aligned with the GOLD groups, the previously established clinical phenotypes couldn't be replicated in a new patient population.
- The inclusion of new variables like quality of life and daily activities led to the formation of distinct clusters, suggesting that using cluster analysis for identifying COPD phenotypes may not effectively guide individual treatment strategies.
Article Synopsis
- Dupilumab, an add-on treatment for severe uncontrolled asthma, shows strong effectiveness and safety based on a real-world study involving 148 patients over 12 months.
- Key findings include a significant decrease in the annual exacerbation rate from 4.00 to 1.00, reduced oral corticosteroid dependency, and improved asthma control and pulmonary function.
- While adverse events were noted in 45.3% of patients, headache being the most common, overall results mirror those of previous phase-III trials, suggesting dupilumab could be a beneficial option in managing severe uncontrolled asthma.
Diagnostic differentiation between asthma and COPD in primary care using lung function testing.
NPJ Prim Care Respir Med
September 2022
Article Synopsis
- Asthma and COPD often present with overlapping symptoms, making it difficult for primary care clinicians to accurately diagnose the conditions.
- A study in 10 Dutch general practices assessed the effectiveness of spirometry and advanced lung function tests in distinguishing between asthma and COPD, involving 532 subjects.
- Results indicated that spirometry significantly improved the ability to differentiate between the two diseases, while more advanced hospital diagnostic tests did not enhance the diagnostic accuracy in a primary care setting.
Article Synopsis
- Asthma patients with obesity face higher disease burdens and often experience low effectiveness from inhaled corticosteroids (ICS), which can also lead to negative side effects like weight gain and diabetes.
- The study, known as the STOP trial, aims to determine if ICS can be safely withdrawn in individuals with T2-low asthma and obesity while maintaining controlled asthma symptoms.
- Participants will be randomly assigned to either a control group receiving ICS or an intervention group that will taper off ICS, followed by a crossover to assess long-term metabolic effects of ICS withdrawal.
Article Synopsis
- Adult-onset asthma (AoA) tends to be more severe than childhood onset asthma (CoA), and this study explored the links between AoA and metabolic conditions, particularly obesity.
- The research involved a comparison of metabolic syndrome and inflammatory markers among patients with AoA, CoA, and healthy controls, using a group of 81 participants from outpatient clinics in Rotterdam.
- Results showed that AoA was significantly linked to metabolic syndrome, with higher levels of inflammatory markers like IL-6 and leptin-adiponectin in AoA patients, suggesting that inflammation related to fat tissue may contribute to the severity of AoA.
Article Synopsis
- * Involving 1006 patients, the research found that 17% experienced acute hyperventilation, and 23% had chronic hyperventilation, with chronic cases more frequent in younger females with better lung function.
- * The conclusion notes that hyperventilation is prevalent in stable asthma patients, but the NQ is not a reliable tool for detecting hyperventilation in this group.
Article Synopsis
- Adults with high BMI are at a greater risk for developing asthma, prompting a study on the link between lipid levels and inflammation in patients with asthma and obesity.
- The research included 96 asthma patients and 45 controls, examining their lipid levels, neutrophils, and eosinophils across a broad BMI range.
- Findings revealed that patients with obesity and asthma had significantly higher serum triglycerides, suggesting that elevated triglycerides might be an overlooked factor contributing to asthma development, though causation was not established.
Article Synopsis
- COVID-19, caused by SARS-CoV-2, is highly contagious and spreads primarily through respiratory droplets and contact with contaminated surfaces, but aerosols also play a significant role in its transmission.
- The virus can remain viable in aerosol form for hours, which can lead to transmission over longer distances and contribute to super-spreader events.
- Effective preventive measures against COVID-19 include social distancing, hygiene practices, and the use of professional-grade masks, particularly important for healthcare workers during specific procedures.
Article Synopsis
- Ehealth platforms are increasingly vital for supporting self-management in COPD patients, especially during the COVID-19 pandemic; this study examines how healthcare professional involvement affects patients' adherence to such platforms.
- The research involved 299 COPD patients, analyzing their usage of the Curavista eHealth platform, comparing those using it independently to those in a blended setting with professional support.
- Results indicated that patients in a blended setting submitted questionnaire responses 3.25 times more frequently, with hospital care showing even higher adherence compared to primary care, highlighting the importance of blended care for effective self-management in COPD.
Article Synopsis
- The impact of COVID-19 has raised concerns about its long-term mental and physical effects, particularly in the Netherlands where there were significant cases, hospitalizations, and deaths during the pandemic.
- The study aims to create an online assessment tool called ABCoV to evaluate the long-term burden of COVID-19 on patients, inspired by existing tools for chronic obstructive pulmonary disease.
- By January 2021, over 2500 patients utilized the ABCoV tool, providing valuable data that may help understand the ongoing challenges faced by COVID-19 survivors.
Article Synopsis
- * The study analyzed exhaled breath from 364 COPD patients who had experienced an exacerbation within the last 3 months, comparing those who did and did not have recent issues.
- * Results showed that eNose could accurately distinguish between exacerbated and stable COPD patients, indicating that exhaled breath may contain unique molecular signatures useful for ongoing patient monitoring.
Article Synopsis
- The study examined the prevalence of nine treatable traits (TTs) in COPD patients at their first visit to a pulmonologist, focusing on how these traits appear together and their impact on health status.
- Data from 402 patients were analyzed, with nine specific TTs identified; these include factors like smoking, fatigue, and depression.
- Results showed an average of 3.9 TTs per patient, with significant correlations found between the number of TTs and poorer health outcomes, particularly regarding fatigue and dyspnoea.*
Article Synopsis
- Preliminary data from various regions, including Wuhan, Northern Italy, and parts of the U.S., indicate a potential link between air pollution levels and the severity of COVID-19 cases.
- In the Netherlands, higher rates of respiratory issues were noted in areas with significant air pollution, particularly in eastern Brabant, where agriculture contributes to elevated particulate matter.
- The research suggests that air pollution might increase susceptibility to severe COVID-19 through mechanisms like the upregulation of certain receptors, highlighting the importance of further studies and the need for stronger air quality regulations.
Background: Numerous instruments have been developed to assess patient reported outcomes; most approaches however focus on a single condition. With the increasing prevalence of multimorbidity, this might no longer be appropriate. Moreover, a more comprehensive approach that facilitates shared decision making and stimulates self-management is most likely more valuable for clinical practice than a questionnaire alone.
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