The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse.

The nuclear lamina is the structural scaffold of the nuclear envelope and is well known for its central role in nuclear organization and maintaining nuclear stability and shape. In the past, a number of severe human disorders have been identified to be associated with mutations in lamins. Extensive research on this topic has provided novel important clues about nuclear lamina function.

[A neglected source text on the history of adrenogenital syndrome. Jean-Baptiste Bouillaud's classification of Valmont's hermaphroditism].

In the early history of the discovery of the adrenogenital syndrome one occasionally comes across case histories that can only be connected with this endocrinological disease because of clinical criteria. In these cases, it it impossible to prove the diagnosis because the adrenal glands and their pathological changes, which constitute the basis of this disease, are not mentioned. One of these uncertain cases claimed to testify to an early knowledge of the adrenogenital syndrome is a hermaphrodite described by the French clinican Bouillaud in 1833.

[Forgotten evidence of adrenogenital syndrome].

At present, the adrenogenital syndrome must surely be reckoned among the most widely known conditions in endocrine pathology. It may come as a surprise that no unambiguous cases of adrenogenitalism are on record before the end of the 19th century. While granting that impressive clinical descriptions may be found in isolated instances, postmortem findings are either totally missing or were not recorded in sufficient detail, thus greatly diminishing their value for retrospective study.