The association of mitochondrial content with prevalent and incident type 2 diabetes.

Context: It has been shown that mitochondrial DNA (mtDNA) content is associated with type 2 diabetes (T2D) and related traits. However, empirical data, often based on small samples, did not confirm this observation in all studies. Therefore, the role of mtDNA content in T2D remains elusive.

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.

Mitochondria play an important role in many processes, like glucose metabolism, fatty acid oxidation and ATP synthesis. In this study, we aimed to identify association of common polymorphisms in nuclear-encoded genes involved in mitochondrial protein synthesis and biogenesis with type II diabetes mellitus (T2DM) using a two-stage design. In the first stage, we analyzed 62 tagging single nucleotide polymorphisms (SNPs) in the Hoorn study (n=999 participants) covering all common variation in 13 biological candidate genes.

Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes.

Purpose Of Review: To discuss the role of mitochondria in the development of type 2 diabetes.

Recent Findings: Some mutations in mitochondrial DNA are diabetogenic due to a gradual decline in insulin secretion by the pancreas. These mutations also result in abnormalities in lipid metabolism.

Do we inherit or acquire mitochondrial dysfunction in the metabolic syndrome and Type 2 diabetes?

The rapid increase in the incidence of Type 2 diabetes mellitus as part of the metabolic syndrome in our current societies is largely the result of an increased caloric intake in combination with a sedentary lifestyle. Mitochondria are the organelles within our body that oxidize the constituents of our food, furthermore, they provide the energy for physical activity. An imbalance between energy supply and energy consumption at the mitochondrial level may be at the basis of the current epidemics of Type 2 diabetes.

New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome.

The 3243A>G mutation in mitochondrial DNA (mtDNA) is a genetic variant that is associated with a high risk of developing diabetes during life. Enhanced aging of pancreatic beta-cells, a reduced capacity of these cells to synthesize large amounts of insulin,and a resetting of the ATP/ADP-regulated K-channel seem to be the pathogenic factors involved.

Molecular mechanisms of mitochondrial diabetes (MIDD).

Mitochondria provide cells with most of the energy in the form of adenosine triphosphate (ATP). Mitochondria are complex organelles encoded both by nuclear and mtDNA. Only a few mitochondrial components are encoded by mtDNA, most of the mt-proteins are nuclear DNA encoded.