Publications by authors named "Johanne Marie Holst"
Myeloproliferative neoplasia (MPN) and lymphoma are regarded as distinct diseases with different pathogeneses. However, patients that are diagnosed with both malignancies occur more frequently in the population than expected. This has led to the hypothesis that the two malignancies may, in some cases, be pathogenetically related.
View Article and Find Full Text PDFLangerhans cell histiocytosis (LCH) is an infrequent disease, characterized by oligoclonal proliferation of immature myeloid-derived cells. However, the exact pathogenesis remains unknown. In rare cases, LCH is present in patients with concomitant myeloid proliferative neoplasms.
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- Galectin-1 (Gal-1) is linked to poor prognosis in various cancers, including some types of lymphoma with CD30 expression, but its role in peripheral T-cell lymphomas (PTCL) had not been thoroughly studied.
- A study analyzed Gal-1 expression in 169 PTCL specimens, finding that while overall survival (OS) wasn't significantly affected by Gal-1 levels in the entire cohort, patients with high Gal-1 in the CD30-positive group had a much worse 5-year OS compared to those with low Gal-1.
- High Gal-1 expression was also associated with fewer cytotoxic T cells in the tumor microenvironment and consistently predicted worse outcomes in both univariate and multivariate analyses.
Objective: Cushing's syndrome (CS) affects all age groups, but epidemiologic data in young patients are very limited. We therefore examined the incidence, prevalence and hospital morbidity of CS in children and adolescents.
Design: In a nationwide cohort study, we included all Danish citizens aged 0-20 years from 1977 to 2012.