Obesity leads to higher glycerol levels in the body and affects glycerol channels (AQP7 and AQP9) in fat and liver tissue, which may play a role in type-2 diabetes.
A study on mice showed that when fed a high-fat diet (HFD), female mice gained less weight and had different glycerol metabolism responses than males, including variations in AQP7 and fatty cell size.
The treatment with the GLP-1 receptor agonist, liraglutide, reduced the negative effects of the HFD on glycerol metabolism, highlighting that responses to the diet are sex-specific in mice.