Sudden Death and Cardiac Arrythmia With Lamotrigine: A Rapid Systematic Review.

Background And Objectives: A recent Food and Drug Administration warning concerning an arrhythmogenic potential of lamotrigine created concern in the neurologic community. This warning was based on in vitro studies, but no clinically relevant risk was considered. This rapid systematic review aims to elucidate the risk of lamotrigine on sudden death or ECG abnormalities.

Medication burden in epilepsy: Exploring the impact of non-epilepsy concomitant drugs load.

Purpose: To determine the burden of non-epilepsy drugs on people with epilepsy, using administrative health care data.

Methods: The Achmea Health Insurance Database (AHID) contains health claims data from 25 % of the Dutch population. From the AHID, we selected all policyholders with coverage for at least one full calendar year between 2006-2009.