Publications by authors named "Johanna Stefanakis"
Article Synopsis
- Dissimilatory sulfite reductase (DsrAB) is a crucial ancient enzyme that has played a key role in the sulfur and carbon biogeochemical cycles for over 3.47 billion years.
- Research has shown that while there are structural features of DsrAB that remain conserved across various lineages, little is known about how these structures adapt as the enzyme evolves in different environments, particularly among ancient sulfate/sulfite-reducing organisms (SROs).
- An analysis using evolutionary sequence co-variance highlighted several inconsistencies (False Positive Evolutionary Couplings) in the structural data, indicating potential regulatory features within the enzyme that may help stabilize its function in diverse conditions.
