Publications by authors named "Johanna Maria Brix"

Introduction: Body size underestimation in patients with obesity may be associated with long-term weight increase. In the current report, we analyse changes in body size perception in patients with obesity undergoing either bariatric surgery or usual obesity care, and in subgroups of patients who gain weight or maintain their body weight over 10 years.

Materials And Methods: A total of 2,504 patients with obesity from the prospective, controlled Swedish Obese Subjects (SOS) intervention study were included in this report, 1,370 patients underwent bariatric surgery and 1,134 patients were usual care controls.

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Bariatric surgery results in significant weight loss, reduction or even remission of obesity-associated comorbidities, reduced mortality, and improved quality of life in many patients; however, obesity is a chronic disease, thus follow-up care is required after bariatric surgery. Furthermore, specific issues, such as micronutrient deficiencies and subsequent complications, can arise both in the short-term and the long-term. Abdominal pain after bariatric surgery must always be regarded as a serious symptom.

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These clinical practice guidelines represent the consensus opinion of a group of Austrian specialist physicians associated with the treatment of obesity. The recommendations incorporate the current literature and guidelines and aim to balance both procedural feasibility and patient acceptance and adherence. Special emphasis was placed on simplification of the preoperative clarification and maximum patient safety.

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The prevalence of overweight and obesity is steadily increasing in Austria as well as internationally. Obesity in particular is associated with multiple health risks, comorbidities, functional disability, and social stigma. Obesity is an independent, complex, chronic disease and should be treated as such by a multidisciplinary team of appropriately qualified personnel.

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Introduction: Cortisol is involved in the regulation of gluconeogenesis and glucose utilization. In morbid obesity (MO), the association of cortisol excretion with metabolic parameters is not well-characterized. In our study, we evaluated cortisol excretion in nondiabetic subjects with MO and its effect on glucose metabolism.

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Introduction: Stunkard's figure rating scale is a widely used tool to assess weight status and, more recently, body image perception in people with obesity. However, large population-based studies on Europeans linking this scale's silhouettes with measured BMI values are lacking. Therefore, we used measured weight and height data from the Swedish Obese Subjects (SOS) reference cohort to assign a mean BMI to each of the 9 Stunkard Scale silhouettes and to define silhouette cutoff values for categorizing people with obesity and overweight.

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Introduction: While vitamin deficiency after bariatric surgery has been repeatedly described, few studies have focused on adequate micronutrient status. In this study, we examine the prevalence of vitamin and micronutrient deficiency for the first 3 years after surgery.

Methods: Out of 1,216 patients undergoing surgery, 485 who underwent postoperative follow-up in an outpatient clinic between 2010 and 2019 were included in this evaluation (76.

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Background And Objectives: Patients with morbid obesity are at an increased risk for cardiovascular and renal complications, which are not only linked to traditional cardiovascular risk factors. Thus, we evaluated (a) the prevalence of albuminuria in non-diabetic and diabetic morbidly obese patients and (b) the effect of weight loss following bariatric surgery.

Material And Methods: We included 1307 patients (77% women, mean age 40 ± 12 years, BMI 45.

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Article Synopsis
  • * Out of 333 patients, 25.6% experienced hypoglycemia after surgery, with the highest occurrence noted in those who had Roux-en-Y gastric bypass (32.6%).
  • * Findings suggest that patients who had hypoglycemia lost more weight and showed significant changes in blood glucose and insulin levels, indicating the need for monitoring glucose levels two years post-surgery to identify at-risk individuals.
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Background: Postoperative micronutrient deficiency is a known side effect of bariatric surgery. In this study, we examined the prevalence of micronutrient deficiency in patients with morbid obesity (MO) preoperatively.

Methods: A total of 1732 patients with MO wishing to undergo bariatric surgery (age: 40 ± 12 years, mean BMI: 44 ± 9 kg/m, means ± SD, 77.

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Objective: YKL-40 is secreted by macrophages in atherosclerotic lesions and involved in plaque rupture. YKL-40 is elevated in coronary artery disease, and predicts cardiovascular mortality. Experimental in vivo and in vitro data suggest a role of YKL-40 in tissue remodeling.

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  • - This study investigates the relationship between thrombin generation (TG) and albuminuria in patients with type 2 diabetes mellitus (T2DM), as albuminuria can indicate cardiovascular risks.
  • - The researchers analyzed 160 T2DM patients, assessing differences in thrombin generation among those with normo-, micro-, and macroalbuminuria, finding significant variations in TG metrics across these groups.
  • - Results revealed that T2DM patients with macrovascular disease had quicker thrombin generation responses compared to those without, suggesting a potential link between thrombin generation disturbances and the progression of diabetic nephropathy.
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  • * Results showed that type 2 diabetes patients with PAD had significantly higher fetuin-A levels than those without complications, and also higher than normal glucose metabolism PAD patients.
  • * The findings suggest a complex relationship where higher fetuin-A is associated with increased prevalence of PAD and myocardial infarction, while being inversely related to mediasclerosis, indicating a potential role of fetuin-A in diabetic complications.
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  • Morbid obesity is linked to increased risks of heart disease and diabetes, but bariatric surgery can help reduce these risks by promoting weight loss.
  • The study measured Fetuin-A levels in 75 morbidly obese patients before and approximately 16 months after they underwent gastric bypass surgery, comparing them to 38 healthy control subjects.
  • Results showed that Fetuin-A levels were significantly higher in morbidly obese patients, and after surgery, these levels decreased along with improvements in insulin resistance, suggesting that lower Fetuin-A levels may contribute to the health benefits observed after gastric bypass.
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Background: Gestational diabetes (GDM) is an increasing and common complication of pregnancy. The involvement of inflammatory mechanisms in GDM remains unclear. YKL-40 is a novel inflammatory marker that has been recently found to be associated with type 2 diabetes.

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Background: Patients suffering from morbid obesity (MO) have an increased cardiovascular morbidity and mortality. This increased cardiovascular burden is believed to be caused by a sub-inflammatory state through an increased secretion of monocyte chemoattractant protein-1 (MCP-1) by the adipose tissue, resulting in insulin resistance (IR) and type 2 diabetes mellitus (T2DM). YKL-40, which is elevated in inflammatory processes in T2DM and IR and in ruptured plaques, might as well be involved in the increased cardiovascular burden of MO patients.

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