Publications by authors named "Johanna M Virtanen"
Purpose Of The Report: The aim of this study was to evaluate the distribution of hypoxia using 18F-EF5 as a hypoxia tracer in cervical cancer patients with PET/MRI. We investigated the association between this 18F-EF5-PET tracer and the immunohistochemical expression of endogenous hypoxia markers: HIF1α, CAIX, and GLUT1.
Patients And Methods: Nine patients with biopsy-proven primary squamous cell cervix carcinoma (FIGO 2018 radiological stages IB1-IIIC2r) were imaged with dual tracers 18F-EF5 and 18F-FDG using PET/MRI (Int J Gynaecol Obstet.
Iron overload in allogeneic hematopoietic cell transplantation outcome: a meta-analysis.
Biol Blood Marrow Transplant
August 2014
An elevated ferritin level before allogeneic hematopoietic cell transplantation (HCT) is an adverse prognostic factor for overall survival (OS) and nonrelapse mortality. Because ferritin is an imperfect surrogate of iron stores, the prognostic role of iron overload remains unclear. We conducted a patient-level meta-analysis of 4 studies that used magnetic resonance imaging to estimate pre-HCT liver iron content (LIC).
View Article and Find Full Text PDFObjective: Infections and graft-versus-host disease (GVHD) are the main causes of transplant-related mortality (TRM) of patients undergoing allo-SCT. The role of iron overload (IO) has been debated in this context. Studies, performed with non-specific surrogate markers of iron, suggest that IO predicts poor outcome after allo-SCT.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess two methods—liver-to-muscle signal intensity and R2*—for measuring liver iron levels with potential clinical applications.
- Research involved 16 liver phantoms and 33 human subjects using three different MRI scanners, which showed strong correlations between the MRI results and actual iron concentrations in both phantoms and human subjects.
- Both methods proved reliable for indicating iron levels, with R2* showing consistency across different scanners, although further testing is necessary to confirm their transferability to various devices.