Publications by authors named "Johanna Lieb"
Article Synopsis
- Elevated levels of activated complement proteins in cerebrospinal fluid (CSF) are linked to increased severity of multiple sclerosis (MS) and correlate with brain imaging and disease biomarkers.
- A study involving 239 patients analyzed various complement components and liquid biomarkers in CSF, finding specific proteins like C4a, Ba, and C3a strongly associated with accelerated brain atrophy and lesion formation.
- Results indicate that higher levels of these complement proteins are predictive of greater brain volume loss and increased development of lesions, suggesting their potential role as biomarkers for disease progression in MS.
Article Synopsis
- Assessment of MS lesions via MRI is usually time-consuming, and the study explores how AI can make this process more efficient for radiologists.* -
- The study involved evaluating MRIs of 35 MS patients, revealing that AI assistance reduced the reading time significantly during follow-ups, while baseline readings showed minimal improvement.* -
- Overall, results indicate that AI can considerably shorten the time needed to assess MRIs for MS, suggesting a more efficient approach for radiologists.*
Background Radially sampled averaged magnetization inversion-recovery acquisition (rAMIRA) imaging shows hyperintensity in the lateral corticospinal tract (CST) in patients with motor neuron diseases. Purpose To systematically determine the accuracy of the lateral corticospinal tract sign for detecting patients with amyotrophic lateral sclerosis (ALS) at rAMIRA MRI. Materials and Methods This study included prospectively acquired data from participants in ALS and other motor neuron disease imaging studies at the University Hospital Basel, Switzerland.
View Article and Find Full Text PDFThe detection of contrast-enhancing lesions (CELs) is fundamental for the diagnosis and monitoring of patients with multiple sclerosis (MS). This task is time-consuming and suffers from high intra- and inter-rater variability in clinical practice. However, only a few studies proposed automatic approaches for CEL detection.
View Article and Find Full Text PDFInitial experiences with magnetic resonance imaging (MRI) of living strangulation victims demonstrated additional findings of internal injuries compared to the standard clinical forensic examination. However, existing studies on the use of MRI for this purpose mostly focused on the first 48 h after the incident. The aims of this study were (a) to evaluate the longitudinal visibility of MRI findings after violence against the neck by performing two MRI examinations within 12 days and a minimum of four days between both MRI scans and (b) to assess which MRI sequences were most helpful for the detection of injuries.
View Article and Find Full Text PDFObjective: To investigate if there is an association between atherosclerosis and depression by using as imaging biomarker the carotid intima media thickness (cIMT), a surrogate marker for atherosclerosis.
Methods: PubMed/Medline, Embase and Cochrane databases were comprehensively searched to identify studies investigating the association between cIMT and depression. The results were pooled using a random-effects statistical model, appropriate for the expected high heterogeneity.
Background And Objectives: The optic nerve is not one of the areas of the CNS that can be used to demonstrate dissemination in space (DIS) within the 2017 McDonald criteria for the diagnosis of multiple sclerosis (MS). Objectives were (1) to assess whether optic nerve-MRI (ON-MRI), optical coherence tomography (OCT), and visual evoked potentials (VEP) detect optic nerve involvement in clinically isolated syndrome (CIS) and (2) to evaluate the contribution of the optic nerve topography to the current diagnostic criteria in a prospective, multicenter cohort.
Methods: MAGNIMS centers were invited to provide prospective data on patients with CIS who underwent a visual assessment with at least 2 of 3 investigations (ON-MRI, OCT, or VEP) within 6 months of onset.
Background And Objectives: Progression independent of relapse activity (PIRA) is a crucial determinant of overall disability accumulation in multiple sclerosis (MS). Accelerated brain atrophy has been shown in patients experiencing PIRA. In this study, we assessed the relation between PIRA and neurodegenerative processes reflected by (1) longitudinal spinal cord atrophy and (2) brain paramagnetic rim lesions (PRLs).
View Article and Find Full Text PDFDoes Functional Imaging Play a Role in Pre-Operative Diagnosis of Brain Tumours?
Fortschr Neurol Psychiatr
September 2023
Although there is a large variability in the neural organization of language function between individuals, there is an ongoing debate about functional imaging as a standard procedure in the preoperative setting of brain tumors. Brain mapping of the language centers differs from individual to individual in multilingual patients and changes in its architecture may occur as a result of neuroplasticity induced by a mass lesion. This article discusses the role of functional imaging in the preoperative setting.
View Article and Find Full Text PDFArticle Synopsis
- Accurate detection of cerebral microbleeds (CMBs) using low-field MRI is being explored as a cost-effective alternative to traditional high-field MRI for evaluating neurological diseases.
- A study involving 24 suspected stroke patients showed that low-field MRI at 0.55 T performed equally well as 1.5 T MRI in identifying CMBs, with both methods achieving 100% sensitivity and specificity.
- Low-field MRI demonstrated better resolution and contrast in imaging quality, while high-field MRI had less noise, suggesting that both methods have their strengths, but low-field MRI could be a beneficial option for resource-limited settings.
Background: Detecting new and enlarged lesions in multiple sclerosis (MS) patients is needed to determine their disease activity. LeMan-PV is a software embedded in the scanner reconstruction system of one vendor, which automatically assesses new and enlarged white matter lesions (NELs) in the follow-up of MS patients; however, multicenter validation studies are lacking.
Purpose: To assess the accuracy of LeMan-PV for the longitudinal detection NEL white-matter MS lesions in a multicenter clinical setting.
Introduction: Measures of cerebral small vessel disease (cSVD), such as white matter hyperintensities (WMH) and cerebral microbleeds (CMB), are associated with an unfavorable clinical course in stroke patients on oral anticoagulation (OAC) for atrial fibrillation (AF). Here, we investigated whether similar findings can be observed for global cortical atrophy (GCA).
Methods: Registry-based prospective observational study of 320 patients treated with OAC following AF stroke.
Growing evidence links COVID-19 with acute and long-term neurological dysfunction. However, the pathophysiological mechanisms resulting in central nervous system involvement remain unclear, posing both diagnostic and therapeutic challenges. Here we show outcomes of a cross-sectional clinical study (NCT04472013) including clinical and imaging data and corresponding multidimensional characterization of immune mediators in the cerebrospinal fluid (CSF) and plasma of patients belonging to different Neuro-COVID severity classes.
View Article and Find Full Text PDFBackground: Growing evidence suggests that the central nervous system is affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), since infected patients suffer from acute and long-term neurological sequelae. Nevertheless, it is currently unknown whether the virus affects the brain cortex. The purpose of this study was to assess the cortical gray matter volume, the cortical thickness, and the cortical surface area in a group of SARS-CoV-2 infected patients with neurological symptoms compared to healthy control subjects.
View Article and Find Full Text PDFBackground: Cerebral microbleeds (CMBs) may have a differential impact on clinical outcome in stroke patients with atrial fibrillation (AF) treated with different types of oral anticoagulation (OAC).
Methods: Observational single-center study on AF-stroke-patients treated with OAC. Magnetic-resonance-imaging was performed to assess CMBs.
Background: A change in MRI hardware impacts brain volume measurements. The aim of this study was to use MRI data from multiple sclerosis (MS) patients and healthy control subjects (HCs) to statistically model how to adjust brain atrophy measures in MS patients after a major scanner upgrade.
Methods: We scanned 20 MS patients and 26 HCs before and three months after a major scanner upgrade (1.
Rationale And Objectives: To assess the effects of a change from free text reporting to structured reporting on resident reports, the proofreading workload and report turnaround times in the neuroradiology daily routine.
Materials And Methods: Our neuroradiology section introduced structured reporting templates in July 2019. Reports dictated by residents during dayshifts from January 2019 to March 2020 were retrospectively assessed using quantitative parameters from report comparison.
Article Synopsis
- Ischemic stroke is a major global health issue, and imaging techniques like CT or MRI are crucial for diagnosis, though MRI is costly and less accessible.
- A study compared brain scans of 27 patients using both a 1.5T and a 0.55T MRI scanner to assess the effectiveness of low-field MRI for detecting stroke lesions.
- Results showed that low-field MRI performed comparably to high-field MRI in diagnosing lesions, with no significant differences in image quality for FLAIR sequences, although 0.55T scans had less noise.
Importance: The mechanisms driving neurodegeneration and brain atrophy in relapsing multiple sclerosis (RMS) are not completely understood.
Objective: To determine whether disability progression independent of relapse activity (PIRA) in patients with RMS is associated with accelerated brain tissue loss.
Design, Setting, And Participants: In this observational, longitudinal cohort study with median (IQR) follow-up of 3.
Objective: Intrathecal Immunoglobulin M synthesis (IgM ) and spinal MRI lesions are both strong independent predictors of higher disease activity and severity in multiple sclerosis (MS). We investigated whether IgM is associated with spinal cord manifestation and higher neuroaxonal damage in early MS.
Methods: In 122 patients with a first demyelinating event associations between (1) spinal versus (vs) non-spinal clinical syndrome (2) spinal vs cerebral T2-weighted (T2w) and (3) contrast-enhancing (CE) lesion counts with IgG (vs IgG ) or IgM (vs IgM ) were investigated by logistic regression adjusted for age and sex, respectively.
Objectives/hypothesis: The anatomy of the posterior glottis, specifically the states of the posterior glottis during phonation, has not been thoroughly explored in laryngology. Conventional wisdom about the posterior glottis indicates that it tends to be completely closed in men but may be open in women. Furthermore, professional singers are expected to have a completely closed posterior glottis.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of intrathecal synthesis of immunoglobulin M (IgM) and immunoglobulin G (IgG) in relapsing multiple sclerosis (MS) and its correlation with disease activity and worsening over time.
- Analysis of data from 530 MS patients shows that those with IgM have significantly shorter times to first relapse and higher MS Severity Scores, along with increased neurofilament light chain levels and T2-weighted MRI lesions.
- The findings suggest that IgM synthesis is an important independent biomarker for assessing disease activity and severity in relapsing MS, differentiating it from patients with only oligoclonal IgG bands.