Publications by authors named "Johanna Kreitz"
Article Synopsis
- * FLT3-ITD promotes the expression of PDP1, leading to increased activity of the pyruvate dehydrogenase complex, which drives metabolic shifts essential for cell proliferation and survival under both normoxic and hypoxic conditions.
- * Targeting PDP1 may present a new strategy for overcoming resistance to FLT3 inhibitors, as its regulation affects glucose metabolism and drug response in AML cells.
Acute myeloid leukemia (AML) is one of the most common and life-threatening leukemias. A highly diverse and flexible metabolism contributes to the aggressiveness of the disease that is still difficult to treat. By using different sources of nutrients for energy and biomass supply, AML cells gain metabolic plasticity and rapidly outcompete normal hematopoietic cells.
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