Publications by authors named "Johanna Korioth"
Background And Purpose: Cancer-induced bone pain remains inadequately controlled, and current standard of care analgesics is accompanied by several side effects. Nociceptin/orphanin FQ peptide (NOP) receptor agonists have demonstrated broad analgesic properties in rodent neuropathic and inflammatory pain models. Here, we investigate the analgesic potential of NOP receptor activation in a rodent cancer-induced bone pain model.
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- - The study investigates how cancer-induced bone pain affects burrowing behavior in mice and rats, which is a natural behavior sensitive to chronic pain.
- - After being inoculated with breast cancer cells, the rodents exhibited decreased bone density and reduced limb use, confirming the presence of the disease.
- - The results show that burrowing performance diminished over time in both models, suggesting that burrowing tests are valuable for evaluating cancer-induced bone pain in research.