Early Empiric Antibiotic Use in Patients Hospitalized With COVID-19: A Retrospective Cohort Study.

Objective: To investigate temporal trends and outcomes associated with early antibiotic prescribing in patients hospitalized with COVID-19.

Design: Retrospective propensity-matched cohort study using the National COVID Cohort Collaborative (N3C) database.

Setting: Sixty-six health systems throughout the United States that were contributing to the N3C database.

The iTHRIV Commons: a cross-institution information and health research data sharing architecture and web application.

Objective: The integrated Translational Health Research Institute of Virginia (iTHRIV) aims to develop an information architecture to support data workflows throughout the research lifecycle for cross-state teams of translational researchers.

Materials And Methods: The iTHRIV Commons is a cross-state harmonized infrastructure supporting resource discovery, targeted consultations, and research data workflows. As the front end to the iTHRIV Commons, the iTHRIV Research Concierge Portal supports federated login, personalized views, and secure interactions with objects in the ITHRIV Commons federation.