Publications by authors named "Johanna Girbardt"
Article Synopsis
- The study investigates the relationship between the thickness of the retinal nerve fiber layer and cognitive performance in individuals aged 40-80, aiming to identify potential early indicators of dementia.
- Conducted as part of the LIFE-Adult study in Germany, researchers analyzed data from over 6,400 participants using various neurocognitive tests and advanced imaging techniques.
- Results indicated that lower cognitive performance is linked to thinner retinal nerve fiber thickness, particularly emphasizing global and temporal regions in the eye.
Purpose: The role of dopamine D-type receptor (DR)-expressing neurons in the regulation of motivated behavior and reward prediction has not yet been fully established. As a prerequisite for future research assessing D-mediated neuronal network regulation using simultaneous PET/MRI and DR-selective [C]SCH23390, this study investigated the stability of central DR measurements between two independent PET/MRI sessions under baseline conditions.
Methods: Thirteen healthy volunteers (7 female, age 33 ± 13 yrs) underwent 90-min emission scans, each after 90-s bolus injection of 486 ± 16 MBq [C]SCH23390, on two separate days within 2-4 weeks using a PET/MRI system.