Publications by authors named "Johanna G Rodriguez"
Article Synopsis
- Cyclic guanosine monophosphate (cGMP) is a second messenger linked to platelet function, but its effects on platelet stiffness and shape were previously unexplored.
- Researchers treated platelets with drugs that stimulate or activate the NO-GC pathway, discovering that these treatments reduced platelet stiffness and changed their shape to be more circular.
- The study suggests that the NO-GC/cGMP pathway could serve as an important biomarker for platelet mechanics, especially in patients at increased risk for blood clotting, such as those with HIV on specific medication regimens.
