Publications by authors named "Johanna Fish"
Postgraduate study can be mentally, physically and emotionally challenging. The levels of anxiety and depression in postgraduate students are much higher than those in the general population, and isolation can also be a problem, especially for students who are marginalised due to gender, race, sexuality, disability or being a first-generation and/or international student. These challenges are not new, but awareness of them has increased over the past decade, as have efforts by institutions to make students feel supported.
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- The text discusses the significance of lipophilicity in drug development, highlighting how structural modifications, especially through fluorine introduction, can optimize both bioactivity and lipophilicity of orally bioavailable drugs.
- It emphasizes the importance of studying fluorinated compounds' octanol-water partition coefficients to enhance understanding of how fluorine affects lipophilicity, which is crucial for computational modeling.
- The findings reveal that skipped fluorination is more effective in reducing log values compared to single or vicinal fluorination, and also detail the efficient synthesis of these compounds, some of which can be made enantioselective.