Publications by authors named "Johanna Daubner"

Objectives: The G72 mouse model of schizophrenia represents a well-known model that was generated to meet the main translational criteria of isomorphism, homology and predictability of schizophrenia to a maximum extent. In order to get a more detailed view of the complex etiopathogenesis of schizophrenia, whole genome transcriptome studies turn out to be indispensable. Here we carried out microarray data collection based on RNA extracted from the retrosplenial cortex, hippocampus and thalamus of G72 transgenic and wild-type control mice.

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A variety of Alzheimer's disease (AD) mouse models has been established and characterized within the last decades. To get an integrative view of the sophisticated etiopathogenesis of AD, whole genome transcriptome studies turned out to be indispensable. Here we carried out microarray data collection based on RNA extracted from the retrosplenial cortex and hippocampus of age-matched, eight months old male and female APP/PS1 AD mice and control animals to perform sex- and brain region specific analysis of transcriptome profiles.

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A variety of Alzheimer disease (AD) mouse models has been established and characterized within the last decades. These models are generated to meet the principal criteria of AD isomorphism, homology and predictability to a maximum extent. To get an integrative view of the sophisticated etiopathogenesis of AD, whole genome transcriptome data analysis turns out to be indispensable.

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Voltage-gated Ca channels (VGCCs) were reported to play a crucial role in neurotransmitter release, dendritic resonance phenomena and integration, and the regulation of gene expression. In the septohippocampal system, high- and low-voltage-activated (HVA, LVA) Ca channels were shown to be involved in theta genesis, learning, and memory processes. In particular, HVA Ca2.

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Early pharmacoepidemiological studies suggested that Proton Pump Inhibitors (PPIs) might increase the risk of Alzheimer's Disease (AD) and non-AD related dementias. These findings were supported by preclinical studies, specifically stressing the proamyloidogenic and indirect anticholinergic effects of PPIs. However, further large-scale pharmacoepidemiological studies showed inconsistent results on the association between PPIs and dementia.

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High voltage-activated Ca2.3 R-type Ca channels and low voltage-activated Ca3.2 T-type Ca channels were reported to be involved in numerous physiological and pathophysiological processes.

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This article provides raw relative electroencephalographic (EEG) power, temperature and activity data from controls and Ca3.2 deficient mice. Radiotransmitter implantation was carried out in male experimental mice under ketamine/xylazine narcosis.

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Recent pharmacoepidemiologic studies suggest that pharmacological neuroenhancement (pNE) and mood enhancement are globally expanding phenomena with distinctly different regional characteristics. Sociocultural and regulatory aspects, as well as health policies, play a central role in addition to medical care and prescription practices. The users mainly display self-involved motivations related to cognitive enhancement, emotional stability, and adaptivity.

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Article Synopsis
  • T-type Ca channels are believed to influence theta oscillations in the hippocampus, and the study used advanced techniques to investigate the role of Ca3.2 channels in this process.
  • The research found that Ca3.2 mice showed increased power in theta frequencies, particularly during inactive phases of the dark cycle, indicating a significant alteration in theta activity after Ca3.2 channel ablation.
  • Analysis also revealed reductions in specific genes related to synaptic function and GABA receptors, suggesting a link between these transcriptional changes and the observed alterations in theta activity.
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