Synopsis of recent research by authors named "Johanna Blees"
- Johanna Blees’ research primarily focuses on the stabilization and functionality of the tumor suppressor protein Pdcd4, investigating its degradation mechanisms and how various compounds can enhance its stability to combat tumorigenesis.
- Her studies employed high-throughput screening methods to identify natural and synthetic stabilizers of Pdcd4, revealing several promising compounds such as tricyclic guanidine alkaloids and actinopolysporins that inhibit its degradation pathways.
- Blees also explored the broader implications of the PI3K-mTOR signaling pathway in cancer progression, linking inflammation and protein degradation processes to loss of Pdcd4 function and contributing to the understanding of potential anti-cancer therapeutics.
