Publications by authors named "Johanna Aro"
Background: Prediction tools that combine polygenic risk scores with clinical factors provide a new opportunity for improved prediction and prevention of atherosclerotic cardiovascular disease, but the clinical utility of polygenic risk score has remained unclear.
Methods: We collected a prospective cohort of 7342 individuals (64% women, mean age 56 years) and estimated their 10-year risk for atherosclerotic cardiovascular disease both by a traditional risk score and a composite score combining the effect of a polygenic risk score and clinical risk factors. We then tested how returning the personal risk information with an interactive web-tool impacted on the participants' health behavior.
Article Synopsis
- A new method for multiplex genotyping of bovine embryo microblade biopsies was developed, allowing simultaneous testing of gene markers associated with milk production and sex diagnosis.
- The method showed high accuracy with only three discrepancies found among 395 genotypes tested, and it demonstrated good embryo viability, recovering 94.6% of biopsied embryos after 24 hours.
- In a practical application, 43 out of 57 selected female embryos were transferred, resulting in 20 successful pregnancies, with calves born being female and matching the genotypes obtained from the biopsies.