Publications by authors named "Johann O Schroeder"
Background & Aims: Altered interactions between the mucosal immune system and intestinal microbiota contribute to pathogenesis of inflammatory bowel diseases (IBD). It is not clear how inhibitors of cytokines, such as antagonists of tumor necrosis factor (anti-TNF), affect the intestinal microbiome. We investigated the effects of anti-TNF agents on gut microbe community structure and function in a longitudinal 2-step study of patients with IBD.
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- - The OBSErve Germany study was the first observational research analyzing belimumab as a supplementary treatment for systemic lupus erythematosus (SLE), involving data from 102 patients before and after starting the medication.
- - After 6 months of treatment, 78% of patients experienced at least a 20% improvement in disease activity, with 42% showing at least a 50% improvement, and notable reductions in SLE Disease Activity Index scores and oral corticosteroid dosage were observed.
- - Belimumab was found to be well-tolerated with a low discontinuation rate (only six patients), indicating promising real-world efficacy for managing SLE.
Differential diagnosis of urticarial skin lesions not representing classic urticaria remains a challenge. Long-lasting nonpruritic urticarial plaques and the histopathologic finding of a dense infiltrate with neutrophil granulocytes are indicative for a rare entity within a group of diseases termed neutrophilic dermatoses. Here, we report a case of neutrophilic urticarial dermatosis characterized by nonpruritic urticarial skin lesions, histopathologic changes resembling Sweet syndrome, and simultaneous Still syndrome.
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