Publications by authors named "Johann Lok"
Article Synopsis
- Aromatase inhibitors (AIs) are medicines used to help treat certain types of breast cancer in women who have gone through menopause by lowering estrogen levels.
- A new study found that a protein called BQ323636.1 (BQ) can cause some breast cancers to become resistant to a specific AI called anastrozole, making it less effective.
- By studying cancer samples, researchers discovered that high levels of both BQ and another protein called androgen receptor (AR) in patients were linked to worse survival rates, suggesting that checking for these proteins could help doctors choose better treatments.
Frozen sections of uterine smooth muscle tumors are infrequently required, and related diagnostic difficulties are seldom discussed. We analyzed the clinicopathologic features of 112 frozen sections of uterine smooth muscle tumors and determined the accuracy, reasons for deferrals, and causes of interpretational errors. Most patients (median age, 45 y) presented with pelvic mass symptoms (53%).
View Article and Find Full Text PDFObjectives: To determine the mechanism and epidemiology of paediatric finger injuries in Hong Kong during 2003-2005 and 2010-2012.
Design: Comparison of two case series.
Setting: University-affiliated teaching hospital, Hong Kong.
Since apoE allele status is the predominant Alzheimer's disease (AD) genetic risk factor, functional single nucleotide polymorphisms (SNPs) in brain apoE receptors represent excellent candidates for association with AD. Recently, we identified a SNP, rs688, as modulating the splicing efficiency of low-density lipoprotein receptor (LDLR) exon 12 in female human liver and in minigene-transfected HepG2 cells. Moreover, the rs688T minor allele was associated with significantly higher LDL and total cholesterol in women within the Framingham Offspring Study cohort.
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