Publications by authors named "Johana Strmiskova"
Article Synopsis
- Human papillomaviruses (HPVs) are double-stranded DNA viruses linked to various cancers, especially cervical cancer, primarily through the integration of their DNA into the host's genome, which leads to genomic instability.
- Traditional detection methods for HPV-related integration face challenges, prompting the development of a new biosensing platform that combines loop-mediated amplification with electrochemical analysis for better specificity in detecting HPV16 integration.
- The study highlights how this platform effectively distinguishes between different forms of HPV16 based on E7 and E2 gene expression in both cell lines and patient cervical tissues, paving the way for improved diagnostics in cervical cancer research.
Persistent infection with high-risk types of human papillomaviruses (HPV) is a major cause of cervical cancer, and an important factor in other malignancies, for example, head and neck cancer. Despite recent progress in screening and vaccination, the incidence and mortality are still relatively high, especially in low-income countries. The mortality and financial burden associated with the treatment could be decreased if a simple, rapid, and inexpensive technology for HPV testing becomes available, targeting individuals for further monitoring with increased risk of developing cancer.
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