modulation of proinflammatory and proteolytic activities of by selected lactobacilli.

Objective: The aim of the present study was to characterize the antimicrobial and anti-inflammatory activities of postbiotics from lactic acid bacteria against .

Material And Methods: The anti- activity of postbiotics from the CERELA culture collection was assessed by measuring changes in the expression of key host proteins by ELISA and qPCR, the proteolytic activity by a fluorescence and a spectrophotometric method and virulence factors from by qPCR.

Results: Even though CRL1522 and CRL1363 exhibit only a discrete antibacterial activity against , the cell-free supernatants of these strains significantly reduced -induced secretion of interleukins IL-6 and IL-8 by keratinocytes and TNF-α and IL-6 by U937 macrophage-like cells.

Improvement of Key Molecular Events Linked to Alzheimer's Disease Pathology Using Postbiotics.

In the past 50 years, life expectancy has increased by more than 20 years. One consequence of this increase in longevity is the rise of age-related diseases such as dementia. Alzheimer's disease (AD) is the most common form of dementia, accounting for 60-70% of cases.