Continuous assessment of intrahepatic metabolism by microdialysis during and after portal triad clamping.

Background: Ischemia-reperfusion injury is a major concern with portal triad clamping (PTC) in liver surgery. Microdialysis allows continuous intraoperative monitoring of tissue metabolism in the liver. Our aim was to evaluate the feasibility of microdialysis as a tool to assess the intrahepatic metabolic effects of PTC in patients undergoing liver resection.

Microdialysis monitoring of porcine liver metabolism during warm ischemia with arterial and portal clamping.

Early detection of vascular complications following liver surgery is crucial. In the present study, intrahepatic microdialysis was used for continuous monitoring of porcine liver metabolism during occlusion of either the portal vein or the hepatic artery. Our aim was to assess whether microdialysis can be used to detect impaired vascular inflow by metabolic changes in the liver.

Hepatic cell membrane damage during cold preservation sensitizes liver grafts to rewarming injury.

Background/purpose: Increasing levels of glycerol in extracellular fluid indicate cell membrane disintegration, and can be continuously monitored with microdialysis. The aim of this study was to monitor liver cell membrane damage during liver transplantation in a pig model.

Methods: Thirteen donor and recipient pairs were divided into two groups; group I, with a liver ischemia time of 5 h (n = 6), and group II, with 15 h of ischemia (n = 7).

Intraperitoneal microdialysis (IPM): a new technique for monitoring intestinal ischemia studied in a porcine model.

Acute mesenteric thrombosis, vascular complications of intestinal transplantation, sepsis, and multiple organ failure are all associated with intestinal ischemia. To improve the outcome of these patients, better monitoring devices are needed. A new technique, intraperitoneal microdialysis (IPM), was evaluated for detection of intestinal ischemia in a porcine model, with the intention of evaluating the technique for future use on humans.

Metabolic changes in the liver graft monitored continuously with microdialysis during liver transplantation in a pig model.

Microdialysis provides the opportunity to continuously monitor metabolic changes in tissue. The aim of the study is to monitor metabolic changes in the liver graft over time during transplantation in a pig model. Fourteen littermate female pigs with a body weight of 30 to 34 kg were used for seven orthotopic liver transplantations.