Publications by authors named "Johan R Bood"
J Appl Physiol (1985)
August 2015
Article Synopsis
- Exercise-induced bronchoconstriction shows refractoriness, meaning there's a reduced reaction to repeat exercise challenges over a few hours, possibly linked to prostaglandin (PG) synthesis.
- A study involving 16 mild asthma patients revealed that a 3-hour interval between exercise challenges resulted in increased urinary excretion of cysteinyl-leukotrienes and PGD2, with a consistent degree of refractoriness of about 15%.
- In a follow-up with 8 subjects, a longer 6-minute challenge displayed a stronger bronchoconstrictor response and a higher degree of refractoriness (30%), confirming that PGE2 and PGI2 could play significant roles in this refractoriness while ruling out mast cell mediator depletion
