Long-term neuropsychological effects of ecstasy in middle-aged ecstasy/polydrug users.

Rationale: Studies reporting ecstasy-induced serotonin-toxicity and (neuro)psychological dysfunctions have been conducted in young adults. Little is known about ecstasy effects later in life, when serotonin levels and cognition decrease as a consequence of normal ageing.

Objective: This study aimed to assess whether harmful effects of ecstasy only add to or also interact with age-related neuropsychological decline.