Integrated treatment of first-episode psychosis: effect of treatment on family burden: OPUS trial.

Background: The families of patients with first-episode psychosis often play a major role in care and often experience lack of support.

Aims: To determine the effect of integrated treatment v. standard treatment on subjective burden of illness, expressed emotion (EE), knowledge of illness and satisfaction with treatment in key relatives of patients with a first episode of schizophrenia-spectrum disorder.