[Arterial thrombosis due to heparin induced thrombocytopenia].

Background: Type II heparin induced thrombocytopenia (HIT) is a procoagulant disorder that is caused by IgG-antibodies against platelet factor 4 (PF4)-heparin (H) complex. Clotting tendency is also increased. This is characterized by a ≥ 50% decrease in platelet count between 5-10 days after exposure to unfractionated or low-molecular weight heparin.

Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial.

Rationale: It is unknown whether lactate monitoring aimed to decrease levels during initial treatment in critically ill patients improves outcome.

Objectives: To assess the effect of lactate monitoring and resuscitation directed at decreasing lactate levels in intensive care unit (ICU) patients admitted with a lactate level of greater than or equal to 3.0 mEq/L.

[Ogilvie Syndrome induced by clozapine].

Clozapine is an antipsychotic drug which is used in the treatment of therapy-resistant schizophrenia. The most frequently reported side effects (occurring in more than 10% of patients) are gastro-intestinal complaints, including constipation. Here we describe the case of a 28-year-old man with schizophrenia who developed constipation and abdominal distension for several weeks while taking clozapine.

[Diagnostic image. A man with dyspnoea].

A 55-year-old man with exertional dyspnoea had a chest X-ray with the Westermark sign and a CT scan showing a Hampton hump. Bilateral pulmonary embolisms were diagnosed.