Finding the Ajoene Sweet-Spot: Structure-Activity Relations that Govern its Blood Stability and Cancer Cytotoxicity.

Ajoene is an organosulfur compound found in crushed garlic that exerts its anti-cancer activity by S-thiolating cysteine residues on proteins. Its development is hampered due to limited bioavailability, so in this study, we synthesised analogues of ajoene to probe the significance of the ajoene vinyl disulfide/sulfoxide core with respect to cytotoxicity and blood stability. Polar side groups were also incorporated to improve aqueous solubility.

Draft Genome Sequences of Seven Type Strains.

In an honors course on "Omics Sciences," draft genome sequences of Chryseobacterium elymi KCTC 22547, Chryseobacterium flavum KCTC 12877, Chryseobacterium hispanicum KCTC 22104, Chryseobacterium lathyri KCTC 22544, " Chryseobacterium massiliae" CCUG 51329, Chryseobacterium piscium CCUG 51923, and Chryseobacterium rhizosphaerae KCTC 22548 were generated to facilitate phylogenomic comparisons within the genus.