Publications by authors named "Johan J Louw"
Article Synopsis
- The study investigates the spontaneous control of HIV/SIV viremia and its association with specific MHC class I allotypes, emphasizing the importance of CD8+ cytotoxic T lymphocytes (CTLs) for managing viral loads.
- Researchers aimed to understand the factors contributing to a phenotype known as elite controllers (ECs) by vaccinating rhesus macaques and analyzing immune responses after infection.
- Results showed that while vaccination did not prevent infection, it led to lower viral levels in vaccinated macaques, and 81% of them achieved elite control, highlighting differences in immune gene expression between vaccinated and unvaccinated groups.
Yellow fever virus (YFV) is a reemerging global health threat, driven by several factors, including increased spread of the mosquito vector and rapid urbanization. Although a prophylactic vaccine exists, vaccine hesitancy, supply deficits, and distribution difficulties leave specific populations at risk of severe YFV disease, as evidenced by recent outbreaks in South America. To establish a treatment for patients with severe YFV infection, we tested 37 YFV-specific monoclonal antibodies isolated from vaccinated humans and identified two capable of potently neutralizing multiple pathogenic primary YFV isolates.
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