Publications by authors named "Johan J B Janssen"
Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until 5 yr postdiagnosis.
Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined.
Real-world palbociclib effectiveness in patients with metastatic breast cancer: Focus on neutropenia-related treatment modification strategies and clinical outcomes.
Cancer Treat Res Commun
May 2023
Article Synopsis
- The study investigates real-world treatment strategies for neutropenia in patients taking palbociclib, focusing on their impact on progression-free survival (PFS) against outcomes in clinical trials.
- Data from 229 patients with HR-positive, HER2-negative metastatic breast cancer were analyzed, revealing different treatment modifications compared to the PALOMA-3 clinical trial, but no significant effect on PFS.
- Patients deemed ineligible for the PALOMA-3 trial had shorter PFS, emphasizing that real-world outcomes may differ from those observed in clinical trials.
Objective: The gold standard for diagnosis of giant cell arteritis (GCA) is a temporal artery biopsy (TAB). We sought for a clinical useful model to predict when an invasive TAB is not necessary to confirm GCA.
Methods: A prospective cohort study was conducted with patients > 50 years with possible GCA, presenting with newly onset headache and/or visual loss.
Regular physical activity (PA) is associated with improved overall survival (OS) in stage I-III colorectal cancer (CRC) patients. This association is less defined in patients with metastatic CRC (mCRC). We therefore conducted a study in mCRC patients participating in the Prospective Dutch Colorectal Cancer cohort.
View Article and Find Full Text PDF