Publications by authors named "Johan Gerritsen"
Article Synopsis
- - The study highlights the role of the cellular environment alongside genetic factors in the onset and progression of diseases, emphasizing that different cell types have unique extracellular needs that influence disease outcomes.
- - It focuses on hsa-microRNA-31-5p (miR-31), which is overexpressed in keratinocytes in psoriatic skin, revealing that its expression increases under low glucose conditions and enhances cell survival by promoting glutamine metabolism.
- - The research demonstrates that miR-31 causes the secretion of specific metabolites and immunomodulatory factors that stimulate Th17 cell differentiation, crucial for psoriasis; targeting this metabolic pathway offers potential treatment strategies as shown in a mouse model.
Question: Does static stretch positioning combined with simultaneous neuromuscular electrical stimulation (NMES) in the subacute phase after stroke have beneficial effects on basic arm body functions and activities?
Design: Multicentre randomised trial with concealed allocation, assessor blinding, and intention-to-treat analysis.
Participants: Forty-six people in the subacute phase after stroke with severe arm motor deficits (initial Fugl-Meyer Assessment arm score ≤ 18).
Intervention: In addition to conventional stroke rehabilitation, participants in the experimental group received arm stretch positioning combined with motor amplitude NMES for two 45-minute sessions a day, five days a week, for eight weeks.