A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity.

Context: Glucagon is produced and released from the pancreatic alpha-cell to regulate glucose levels during periods of fasting. The main target for glucagon action is the liver, where it activates gluconeogenesis and glycogen breakdown; however, glucagon is postulated to have other roles within the body.

Objective: We sought to identify the circulating metabolites that would serve as markers of glucagon action in humans.