Publications by authors named "Johan G Doverfjord"
Article Synopsis
- Early detection of liver fibrosis is challenging, but PDGFR-β is being explored as a biomarker, and a new compound, [Ga]Ga-BOT5035, targets this marker for better diagnosis and treatment monitoring.
- The production of [Ga]Ga-BOT5035 was successfully automated using GMP methods in a lab, ensuring consistent quality and quantity.
- Radiation dosimetry calculations were performed to enable multiple, safe annual scans for patients in a clinical setting.
: [Ga]Ga-DO3A-VS-Cys-Tuna-2 (previously published as [Ga]Ga-DO3A-VS-Cys-S01-GCG) has shown high-affinity specific binding to the glucagon receptor (GCGR) in vitro and in vivo in rats and non-human primates in our previous studies, confirming the suitability of the tracer for drug development applications in humans. The manufacturing process of [Ga]Ga-DO3A-VS-Cys-Tuna-2 was automated for clinical use to meet the radiation safety and good manufacturing practice (GMP) requirements. The automated synthesis platform (Modular-Lab PharmTrace, Eckert & Ziegler, Eurotope, Germany), disposable cassettes for Ga-labeling, and pharmaceutical-grade Ge/Ga generator (GalliaPharm) used in the study were purchased from Eckert & Ziegler.
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