Accuracy of patient-specific I-131 dosimetry using hybrid whole-body planar-SPECT/CT I-123 and I-131 imaging.

Purpose: This study aimed to assess the accuracy of patient-specific absorbed dose calculations for tumours and organs at risk in radiopharmaceutical therapy planning, utilizing hybrid planar-SPECT/CT imaging.

Methods: Three Monte Carlo (MC) simulated digital patient phantoms were created, with time-activity data for mIBG labelled to I-123 (LEHR and ME collimators) and I-131 (HE collimator). The study assessed the accuracy of the mean absorbed doses for I-131-mIBG therapy treatment planning.

Characterization of Gafchromic™ film response against radionuclide activity.

Purpose: In this study, we used Gafchromic™ film XR-QA2 and RT-QA2 to characterize the film energy response against various radionuclides. We introduce a neutron depletion theoretical model that can describe film response as a function of cumulated activity. The film response was investigated with respect to different backscatter media such as polystyrene, perspex, lead and corrugated fibreboard carton (CFC).

Evaluation of Iodine-123 and Iodine-131 SPECT activity quantification: a Monte Carlo study.

Purpose: The quantitative accuracy of Nuclear Medicine images, acquired for both planar and SPECT studies, is influenced by the isotope-collimator combination as well as image corrections incorporated in the iterative reconstruction process. These factors can be investigated and optimised using Monte Carlo simulations. This study aimed to evaluate SPECT quantification accuracy for I with both the low-energy high resolution (LEHR) and medium-energy (ME) collimators and I with the high-energy (HE) collimator.

Validation of a SIMIND Monte Carlo modelled gamma camera for Iodine-123 and Iodine-131 imaging.

Purpose: Monte Carlo (MC) modelling techniques can assess the quantitative accuracy of both planar and SPECT Nuclear Medicine images. It is essential to validate the MC code's capabilities in modelling a specific clinical gamma camera, for radionuclides of interest, before its use as a clinical image simulator. This study aimed to determine if the SIMIND MC code accurately simulates emission images measured with a Siemens Symbia™ T16 SPECT/CT system for I-123 with a LEHR and a ME collimator and for I-131 with a HE collimator.

Modelling of energy-dependent spectral resolution for SPECT Monte Carlo simulations using SIMIND.

Purpose: Monte Carlo (MC) modelling techniques have been used extensively in Nuclear Medicine (NM). The theoretical energy resolution relationship ( ), does not accurately predict the gamma camera detector response across all energies. This study aimed to validate the accuracy of an energy resolution model for the SIMIND MC simulation code emulating the Siemens Symbia T16 dual-head gamma camera.

Biodistribution (as determined by the radiolabelled equivalent) of a gold(III) bis(pyrrolide-imine) Schiff base complex: a potential chemotherapeutic.

The biodistribution of an N2 N2 ' tetradentate gold(III) chelate, which is known to be cytotoxic towards a range of human cancer cell lines, was determined by a radiolabelled equivalent of the compound. The (198) Au-labelled gold(III) chelate of a bis(pyrrolide-imine) Schiff base ligand with a three-carbon di(azomethine) linkage was successfully synthesised with a high radiochemical yield of 73% and radiochemical purity of >95%. The high energy γ-ray emitted by the (198) Au nucleus was used to follow the biodistribution of the compound in vivo in six male Sprague Dawley rats on a gamma camera.

Enhanced myocardial contractility associated with hypercalcaemia of hyperparathyroidism - a case study in six patients.

The possible association of increased left ventricular ejection fraction (LVEF) in patients with increased serum Ca(2+) was observed in our clinic. Six patients with confirmed primary hyperparathyroidism and hypercalcaemia were studied prospectively. Tc-99m sestamibi gated SPECT was done pre- and postoperatively.