Publications by authors named "Joffrey Pozzo"
Aims: Tenascin-C (TNC) is an endogenous danger signal molecule strongly associated with inflammatory diseases and with poor outcome in patients with cardiomyopathies. Its function within pathological cardiac tissue during pressure overload remains poorly understood.
Methods And Results: We showed that TNC accumulates after 1 week of transverse aortic constriction (TAC) in the heart of 12-week-old male mice.
• Coronary artery perforation was related to angiosarcoma with prior radiation therapy. • Pericardial effusion must make a neoplastic origin suspicious, even from coronary arteries. • Angiosarcomas are rare complications of radiotherapy that must be considered in case of complex situations.
View Article and Find Full Text PDFBackground: Functional status is one of the main concerns in the management of heart failure (HF). Recently, the FAIR-HF and CONFIRM-HF trials showed that correcting anaemia using intravenous iron supplementation improved functional variables in patients with absolute or relative iron deficiency. Relative iron deficiency is supposed to be a marker of HF severity, as ferritin concentration increases with advanced stages of HF, but little is known about the impact of absolute iron deficiency (AID).
View Article and Find Full Text PDFObesity Paradox: Origin and best way to assess severity in patients with systolic HF.
Obesity (Silver Spring)
October 2015
Objective: Obesity in patients with heart failure (HF) is a factor of better prognosis, supposedly partly because of the particular epidemiology of HF in this population. This study expected to compare the parameters of severity and mortality in patients with and without obesity, to better understand the origin of this paradox.
Methods: Two hundred twenty-two patients with nonischemic HF and systolic dysfunction were divided into two groups according to their body mass index (≥ 30 vs.
Article Synopsis
- - LEOPARD syndrome, also known as Noonan syndrome with multiple lentigines, is a rare genetic disorder characterized by various developmental issues including heart defects, distinct physical features, short stature, and growth retardation, primarily due to PTPN11 gene mutations.
- - In a study using a mouse model with a common LS mutation, researchers found that these mice had significantly less body fat and were resistant to obesity, suggesting that the mutation impacts fat storage and energy expenditure.
- - Preliminary findings from human patients indicate that many affected individuals also have lower body mass index (BMI) and reduced fat, revealing potential metabolic benefits from the disorder while possibly complicating certain aspects of health related to LS.
Background: The mechanisms by which the heart adapts to chronic pressure overload, producing compensated hypertrophy and eventually heart failure (HF), are still not well defined. We aimed to investigate the involvement of T cells in the progression to HF using a transverse aortic constriction (TAC) model.
Methods And Results: Chronic HF was associated with accumulation of T lymphocytes and activated/effector CD4(+) T cells within cardiac tissue.