Publications by authors named "Joffi Musonge-Effoe"
Purpose Of Review: As advances in antiretroviral therapy for people with HIV (PWH) have prolonged lifespans, prevalence of aging and obesity related metabolic disorders have increased. The purpose of this review is to summarize recent research assessing sex differences in metabolic disorders among PWH, including weight gain/obesity, steatotic liver disease, insulin resistance/diabetes, dyslipidemia, bone loss/osteoporosis, and sarcopenia.
Recent Findings: A growing body of evidence shows that women with HIV are at increased risk of developing metabolic disorders compared to men, including body weight gain and obesity, type 2 diabetes mellitus, dyslipidemia, bone loss, and sarcopenia, while men with HIV are at higher risk for hepatosteatosis and hepatic fibrosis.
Article Synopsis
- A study investigated long-term body weight changes in people with HIV (PWH) who switched to antiretroviral therapies containing integrase strand-transfer inhibitors (INSTIs), comparing them with those on non-INSTI therapies and people without HIV (PWOH).
- The analysis included 3464 participants and revealed that women experienced significantly greater weight gain and increases in hip and thigh circumference after switching to INSTIs compared to men, with women gaining +3.0 kg and men +1.8 kg over 5 years.
- The findings suggest a 2-fold higher weight change in women versus men following the switch to INSTIs, although the long-term health implications of this difference are still uncertain.
Background: There is limited data on the difference in the clinical characteristics and outcomes of patients with severe coronavirus disease 2019 (COVID-19) infection in the summer compared to the fall surge.
Aim: To compare the sociodemographic, clinical characteristics, and outcomes among mechanically ventilated patients with severe COVID-19 infection admitted to the intensive care unit (ICU) during the summer and fall surges in the year 2020.
Methods: We included patients admitted to the ICU and treated with invasive mechanical ventilation for COVID-19 associated respiratory failure between April 1 and December 31, 2020.
Article Synopsis
- This study examined trends in ischemic stroke incidence in patients with takotsubo cardiomyopathy (TCM) from 2008 to 2017, focusing on the differences between thrombotic and cardioembolic strokes.
- Out of 27,970 hospitalized TCM patients, 751 (3%) had ischemic strokes, with 76% classified as thrombotic and 24% as cardioembolic; the study found an increase in thrombotic strokes over the years, while cardioembolic rates remained stable.
- Factors like peripheral artery disease and prior strokes were linked to thrombotic strokes, while cardiogenic shock and atrial fibrillation were associated with cardioembolic strokes, both types of
Persons without health care coverage have poorer health outcomes. We investigated the association between health care coverage and trends in the prevalence of cardiovascular disease (CVD) and diabetes pre- and post-Affordable Care Act (ACA) periods. Using data from 3,824,678 surveyed adults in the Behavioral Risk Factor Surveillance System survey from 2007 - 2016, we calculated the yearly prevalence of CVD and diabetes.
View Article and Find Full Text PDFAbdominal tuberculosis (TB) may affect any part of the gastrointestinal tract resulting in significant morbidity and mortality. There is an increase in the incidence of abdominal TB favored by the emergence of multi-drug resistant Mycobacterium tuberculosis and immunosuppression especially from HIV co-infection. Our case is that of a 31 year old HIV-positive woman, adherent to antiretroviral therapy, who presented with a 2 month history of progressive abdominal distention, drenching night sweat and fatigue, but without fever.
View Article and Find Full Text PDF