Hydrogel-Based Spheroid Models of Glioblastoma for Drug Screening Applications.

Glioblastoma multiforme (GBM) is the most aggressive brain tumor, with median patient survival of 12-15 months even after treatment. To facilitate basic research as well as treatment development, bioengineered GBM models that adequately recapitulate aspects of the in vivo tumor microenvironment are greatly needed. Multicellular spheroids are a well-accepted model in tumor biology as well as drug screening because they recapitulate many of the solid tumor characteristics, such as hypoxic core and cell-cell communication.