Mebeverine and the influence of labeling in adolescents with irritable bowel syndrome or functional abdominal pain-NOS: a 2x2 randomized, placebo-controlled trial.

Background And Aims: Pediatric irritable bowel syndrome (IBS) and functional abdominal pain - not otherwise specified (FAP-NOS) lack effective pharmacologic interventions. We evaluated the efficacy of mebeverine, an antispasmodic agent, and the effect of labeling within a pediatric cohort.

Methods: This randomized trial was conducted across 13 hospitals.

The low FODMAP diet in adolescents functional abdominal in a non-guided setting: a prospective multicenter cohort study.

Unlabelled: The purpose of this study is to evaluate the efficacy of a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) in adolescents with irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) in a non-guided setting, resembling clinical practice. This prospective multicenter cohort study conducted in 13 centers included patients aged 12-18 years diagnosed with IBS or FAP-NOS. Patients received educational material on FODMAPs, including extensive lists of high and low FODMAP foods and additional online information.

Current treatment practice of functional abdominal pain disorders in children: A multicenter survey.

Background: Approximately 90% of the children with chronic abdominal pain are diagnosed as having functional abdominal pain disorder (FAPD). The Dutch guideline "functional abdominal pain" provides a stepwise approach to treat FAPD. The aim of this survey was twofold first, to determine adherence to the Dutch guideline, and second to determine current management of FAPDs in clinical practice.

Skills or Pills: Randomized Trial Comparing Hypnotherapy to Medical Treatment in Children With Functional Nausea.

Background & Aims: The potential effectiveness of gut-directed hypnotherapy (HT) is unknown for pediatric chronic nausea. This randomized controlled trial compared HT with standard medical treatment (SMT).

Methods: One hundred children (ages, 8-18 y) with chronic nausea and fulfilling functional nausea (FN) or functional dyspepsia (FD) criteria were allocated randomly (1:1) to HT or SMT, with a 3-month intervention period.

Gut-directed hypnotherapy versus standard medical treatment for nausea in children with functional nausea or functional dyspepsia: protocol of a multicentre randomised trial.

Introduction: The treatment of chronic functional nausea or nausea due to functional dyspepsia in children is generally symptomatic. Moreover, these disorders pose a risk for worse psychosocial and health outcomes in children. Hypnotherapy (HT), by its ability to positively influence gastrointestinal and psychosocial functioning, may be an effective treatment for chronic nausea.

New reference charts for testicular volume in Dutch children and adolescents allow the calculation of standard deviation scores.

Aim: Accurate calculations of testicular volume standard deviation (SD) scores are not currently available. We constructed LMS-smoothed age-reference charts for testicular volume in healthy boys.

Methods: The LMS method was used to calculate reference data, based on testicular volumes from ultrasonography and Prader orchidometer of 769 healthy Dutch boys aged 6 months to 19 years.

Long-term testicular volume after orchiopexy at diagnosis of acquired undescended testis.

Purpose: We studied long-term outcomes of orchiopexy at diagnosis of acquired undescended testes using ultrasound to determine testicular volume.

Materials And Methods: Patients who had undergone orchiopexy for acquired undescended testis at diagnosis were recruited to assess testicular volume. Testis volume was measured by ultrasound and compared with recently developed normative values for testicular size.

Testicular microlithiasis in two boys with a chromosomal abnormality.

A nine and 13-year-old boy, previously diagnosed with 18q syndrome and an 11q deletion, respectively were diagnosed with testicular microlithiasis (TM). Both cases demonstrate that TM occurs in patients with various chromosomal abnormalities.

High prevalence of intratesticular varicocele in a post-orchidopexy cohort.

Purpose: Intratesticular varicocele (ITV) is an uncommon sonographic finding. A prevalence of up to 2% has been reported in men with testicular problems. In a cohort of men who had undergone prepubertal orchidopexy for acquired undescended testis, several cases of ITV were found.

Long-term testicular position and growth of acquired undescended testis after prepubertal orchidopexy.

Purpose: The aim of the study was to determine long-term testicular position and growth of acquired undescended testis (UDT) after prepubertal orchidopexy.

Methods: Patients who had undergone prepubertal orchidopexy for acquired UDT at our hospital between 1986 and 1999 were recruited to assess long-term testicular position and volume. Testis position was assessed by physical examination.

Testicular volume and testicular microlithiasis in boys with Down syndrome.

Purpose: Studies have suggested that testicular microlithiasis and Down syndrome are linked, yet a correlation remains unclear. We investigated the prevalence of testicular microlithiasis in patients with Down syndrome. We hypothesized that testicular microlithiasis is present at a higher rate in these patients.

Testicular microlithiasis in boys and young men with congenital or acquired undescended (ascending) testis.

Purpose: We assessed the prevalence of testicular microlithiasis by ultrasound in boys and young men with congenital or acquired undescended (ascending) testis.

Materials And Methods: During followup for testicular growth patients with congenital or acquired undescended (ascending) testis were also screened by ultrasound for testicular microlithiasis, which was defined as echogenic foci without shadowing within the testis parenchyma. Classic microlithiasis was defined as 5 or more echogenic foci in either or both testes and limited microlithiasis as fewer than 5 foci.

Natural history and long-term testicular growth of acquired undescended testis after spontaneous descent or pubertal orchidopexy.

Objective: To assess prospectively the natural history and long-term testicular growth of acquired undescended testis (UDT) after spontaneous descent or pubertal orchidopexy in case of nondescent.

Patients And Methods: From 1996 until 2008, 391 boys with 464 acquired UDT were included in the study. In accordance with Dutch consensus on non-scrotal testes, spontaneous descent at puberty was awaited; if this did not take place, orchidopexy was performed at puberty.