Publications by authors named "Joern Decker"
J Biol Chem
December 2024
Article Synopsis
- Erythropoiesis, the formation of red blood cells, is regulated by transcription factors like TAL1, which either activate or repress gene expression through epigenetic mechanisms.
- TAL1 works with the cofactor PRMT6 to regulate the ID3 gene, essential for hematopoietic cell differentiation, by modifying histones and affecting ID3 expression.
- Enhancing ID3 expression through manipulation may improve the in vitro differentiation of stem cells (hCD34+) into erythrocytes, providing insights into both normal and pathological red blood cell development.
