Evolution of anti-MICA antibodies after imlifidase infusion for a high immunological risk kidney transplantation.

Imlifidase is an endopeptidase known for cleaving anti-Human Leucocyte Antigen donor-specific antibodies (DSA) to allow high-risk kidney transplantation. However, it lacks comprehensive data regarding its effect on alloantibodies targeting other histocompatibility antigens, such as Major Histocompatibility Complex class I chain-related protein A (MICA). This study describes the dynamics of anti-MICA antibodies following imlifidase administration in a kidney transplant recipient with anti-MICA*002 preformed DSA.

Building Family Medicine Research Through Community Engagement: Leveraging Federal Awards to Develop Infrastructure.

Many academic departments and programs struggle with the challenge of how to begin a meaningful research program. A useful place to start is with the work they already are doing in communities. Using work in practices and other clinical venues as a springboard can build helpful relationships that can catalyze research and build infrastructure that matters to family medicine clinicians, researchers, and the communities they serve.

Developing, implementing, and evaluating the first national Memory and Cognition Clinic Guidelines in Australia.

Introduction: A lack of national consensus on the roles and responsibilities of Australian memory and cognition clinics contributes to the large variability seen across services. The introduction of guidelines and a quality assessment framework could facilitate greater harmonization and quality improvements.

Methods: We used a modified Delphi process to develop the guidelines.

Comparison of integrated versus parallel continuous renal replacement therapy combined with veno-venous extracorporeal membrane oxygenation in patients with COVID-19 ARDS.

Introduction: Acute kidney injury (AKI) is a common complication of acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MODS) in patients receiving extracorporeal membrane oxygenation (ECMO) support, leading to requirement of continuous renal replacement therapy (CRRT) in 70% of ECMO patients. Parallel arrangement of CRRT and ECMO circuits is common in adult patients. However, CRRT may also be integrated directly into the ECMO circuit.

Examining changes in fatal violence against women after bail reform in New Jersey.

Introduction Cash bail reforms that end pretrial detention due to the inability to afford bail have been highly debated across the US. A major concern cited by bail reform opponents is that reducing pretrial detention will increase community violence, particularly violence against women. The objective of this study was to assess if New Jersey's cash bail reform was associated with changes in rates of fatal violence against women.

Deep learning empowered sensor fusion boosts infant movement classification.

Background: To assess the integrity of the developing nervous system, the Prechtl general movement assessment (GMA) is recognized for its clinical value in diagnosing neurological impairments in early infancy. GMA has been increasingly augmented through machine learning approaches intending to scale-up its application, circumvent costs in the training of human assessors and further standardize classification of spontaneous motor patterns. Available deep learning tools, all of which are based on single sensor modalities, are however still considerably inferior to that of well-trained human assessors.

Liquid Structure of Magnesium Aluminates.

Magnesium aluminates (MgO)(AlO) belong to a class of refractory materials with important applications in glass and glass-ceramic technologies. Typically, these materials are fabricated from high-temperature molten phases. However, due to the difficulties in making measurements at very high temperatures, information on liquid-state structure and properties is limited.

Addressing inter individual variability in CSF levels of brain derived proteins across neurodegenerative diseases.

Accurate diagnosis and monitoring of neurodegenerative diseases require reliable biomarkers. Cerebrospinal fluid (CSF) proteins are promising candidates for reflecting brain pathology; however, their diagnostic utility may be compromised by natural variability between individuals, weakening their association with disease. Here, we measured the levels of 69 pre-selected proteins in cerebrospinal fluid using antibody-based suspension bead array technology in a multi-disease cohort of 499 individuals with neurodegenerative disorders including Alzheimer's disease (AD), behavioral variant frontotemporal dementia, primary progressive aphasias, amyotrophic lateral sclerosis (ALS), corticobasal syndrome, primary supranuclear palsy, along with healthy controls.

Overlapping qubits from non-isometric maps and de Sitter tensor networks.

The emergence of a local effective theory from a more fundamental theory of quantum gravity with seemingly fewer degrees of freedom is a major puzzle of theoretical physics. A recent approach to this problem is to consider general features of the Hilbert space maps relating these theories. In this work, we construct approximately local observables, or overlapping qubits, from such non-isometric maps.

Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors.

Resistance to chimaeric antigen receptor (CAR) T cell therapy develops through multiple mechanisms, most notably antigen loss and tumour-induced immune suppression. It has been suggested that T cells expressing multiple CARs may overcome the resistance of tumours and that T cells expressing receptors that switch inhibitory immune-checkpoint signals into costimulatory signals may enhance the activity of the T cells in the tumour microenvironment. However, engineering multiple features into a single T cell product is difficult because of the transgene-packaging constraints of current gene-delivery vectors.

A biopsychosocial approach towards understanding disparities in exercise participation between Hispanic and non-Hispanic White patients living with knee osteoarthritis.

Engaging in regular exercise is essential for managing knee osteoarthritis (KOA) symptoms. Despite the established findings, sustained exercise adoption remains a challenge for KOA patients, with notable disparities among Hispanic patients, warranting a need to identify determinants that explain the racial discrepancy in exercise participation. The purpose of this study was to employ a biopsychosocial model to identify determinants of exercise participation and highlight racial disparities.

Evaluations of digital public health interventions in the WHO Southeast Asia Region: a systematic literature review.

Introduction: Digital health technologies have been enhancing the capacity of healthcare providers and, thereby, the delivery of targeted health services. The Southeast Asia Region (SEAR) has invested in strengthening digital public health. Many digital health interventions have been implemented in public health settings but are rarely assessed using the holistic health technology assessment (HTA) approach.

Correction: Muñoz-Villagrán et al. The Thioredoxin Fold Protein (TFP2) from Extreme Acidophilic sp. CF-1 Is a Chaperedoxin-like Protein That Prevents the Aggregation of Proteins under Oxidative Stress. 2024, , 6905.

Susanne Sievers and Daniela Zühlke were not included as authors in the original publication [...

Golgi pH elevation due to loss of V-ATPase subunit V0a2 function correlates with tissue-specific glycosylation changes and globozoospermia.

Loss-of-function variants in ATP6V0A2, encoding the trans Golgi V-ATPase subunit V0a2, cause wrinkly skin syndrome (WSS), a connective tissue disorder with glycosylation defects and aberrant cortical neuron migration. We used knock-out (Atp6v0a2) and knock-in (Atp6v0a2) mice harboring the R755Q missense mutation selectively abolishing V0a2-mediated proton transport to investigate the WSS pathomechanism. Homozygous mutants from both strains displayed a reduction of growth, dermis thickness, and elastic fiber formation compatible with WSS.

Reparations for African Enslavement in the U.S. and Black Survival Using the Panel Study of Income Dynamics.

Activists, policymakers, and scholars increasingly have advocated for reparations payments to Black Americans to redress the harms of enslavement and discriminatory practices that followed. This study examined the effects of a hypothetical monetary reparations intervention on all-cause premature and overall mortality among Black adults in the U.S.

Novel assembly of the SF370 strain of the important human pathogen serotype M1.

The important human pathogen causes a wide range of diseases. Strain SF370 was the first fully sequenced strain of , providing essential insights into the molecular mechanisms of disease. We present an improved genome assembly of strain SF370 from ATCC, which corrects long-standing errors in its genome.

Neuroarchitecture of the Central Complex in the Madeira Cockroach Rhyparobia maderae: Tangential Neurons.

Navigating in diverse environments to find food, shelter, or mating partners is an important ability for nearly all animals. Insects have evolved diverse navigational strategies to survive in challenging and unknown environments. In the insect brain, the central complex (CX) plays an important role in spatial orientation and directed locomotion.

Comparison of Ocular Biometry Measurements from Two Swept-Source OCT Devices: Eyestar 900 vs. Anterion.

Background: Advanced swept-source optical coherence tomography (SS-OCT) devices are the current gold standard for the measurement of ocular biometric and keratometric parameters, which are essential for the calculation and selection of intraocular lenses (IOLs). This study compares the agreement of two SS-OCT devices, the Eyestar 900 (Haag-Streit, Köniz, Switzerland) and the Anterion (Heidelberg Engineering, Heidelberg, Germany).

Materials And Methods: All patients undergoing cataract surgery or seeking consultation for corneal abnormalities between January 2024 and May 2024 were eligible for inclusion.

The first ice-free day in the Arctic Ocean could occur before 2030.

Projections of a sea ice-free Arctic have so far focused on monthly-mean ice-free conditions. We here provide the first projections of when we could see the first ice-free day in the Arctic Ocean, using daily output from multiple CMIP6 models. We find that there is a large range of the projected first ice-free day, from 3 years compared to a 2023-equivalent model state to no ice-free day before the end of the simulations in 2100, depending on the model and forcing scenario used.

Substitution patterns and price response for plant-based meat alternatives.

Efforts to promote sustainable resource use through reduced meat consumption face challenges as global meat consumption persists. The resistance may be attributed to the lower sales price of meat compared to most plant-based meat alternatives (PBMAs). Addressing this, our research delves into the pivotal question of which PBMAs resonate most with consumers and how pricing affects demand.

Sex differences in MAGEL2 gene promoter methylation in high functioning autism - trends from a pilot study using nanopore Cas9 targeted long read sequencing.

Background: MAGEL2 is an autism susceptibility gene whose deficiency has been associated with autism-related behaviors in animal models and in syndromic human autism spectrum disorders (ASDs) such as Schaaf-Yang syndrome, but has not been studied in the broader autism spectrum. Given the capabilities of long-read sequencing technologies, this pilot study used a targeted nanopore sequencing approach to simultaneously examine MAGEL2 DNA sequence and methylation in adults with high-functioning autism (HFA) compared to neurotypical controls (NC).

Methods: Using DNA extracted from peripheral blood, Cas9-targeted nanopore DNA sequencing was used to analyze MAGEL2, including its entire regulatory construct (chr15:23639316-23651466), for sequence variation and 5-methyl-cytosine (5mC) modification in a cohort of adults with HFA compared to sex- and age-matched NC.