Stimulation of bone growth factor synthesis in human osteoblasts and fibroblasts after extracorporeal shock wave application.

Background: Nonunion is a common problem in Orthopedic Surgery. In the recent years alternatives to the standard surgical procedures were tested clinically and in vitro. Extracorporeal shock wave therapy (ESWT) showed promising results in both settings.

Influence of clamp duration and pressure on endothelial damage in aortic cross-clamping.

Aortic cross-clamping during cardiac operations may injure the vessel wall and cause tissue lesions. This experimental study analyses the influence of the intravascular and external pressure and the duration of aortic cross-clamping on endothelial tissue damage. Fresh porcine aortas (n=20) were tested with intravascular pressures from 30 to 80 mmHg.

Impact of graft size and commissural resuspension height on aortic valve competence in valve-sparing aortic replacement under physiological pressures.

Background: Valve competence in valve-sparing aortic root replacement has been described as being influenced by commissural height as well as graft size. The aim of this study was to investigate the impact of a gradual reduction of commissural height and graft diameter on aortic insufficiency under physiological conditions in an IN VITRO model.

Methods: Porcine aortic valves were reimplanted into a tubular graft and a native commissural height was obtained.

In-vitro hemodynamics of stented bioprosthetic heart valves in the tilted implantation position.

Background And Aim Of The Study: Although, in small aortic annulus or aortic annulus calcification, it is recommended that valves are implanted in a tilted position, mechanical valves show impaired hemodynamic performance when positioned in this way. To date, no investigations have been conducted with biological valves implanted in a tilted position.

Methods: Measurements were performed in a pulsatile flow simulator.