Publications by authors named "Joerg Seebach"
Article Synopsis
- Desmoplakin cardiomyopathy is a recently defined heart condition causing left ventricular dysfunction, often leading to inflammation, fibrosis, and arrhythmias.
- A case study highlights a 46-year-old woman with this condition, who experienced multiple cardiac arrests due to a new variant in the desmoplakin gene and showed little improvement after receiving immunosuppressive treatment.
- The condition should be included in the evaluation of inflammatory heart diseases, and while some patients may benefit from immunosuppressive therapy, its effectiveness remains largely unknown.
The study of reactions to SARS-CoV-2 vaccines has marked a large part of the literature in the last two years, using the basophil activation test (BAT) as a potential diagnostic tool for reactions to Covid-19 vaccines. In allergic rhinoconjunctivitis, lirentelimab (a humanised monoclonal antibody against lectin 8), reduces patients' symptoms and atopic comorbidities. In severe asthma, tezepelumab (human monoclonal antibody) reduces the annual asthma exacerbation rate over 52 weeks.
View Article and Find Full Text PDFIntroduction: Patients undergoing immunosuppressive therapy are at increased risk of infection. Community-acquired pneumonia and invasive pneumococcal disease account for substantial morbidity and mortality in this population and may be prevented by vaccination. Ideally, immunization to pneumococcal antigens should take place before the start of immunosuppressive treatment.
View Article and Find Full Text PDFAsthma is one of the most common chronic diseases in Switzerland. Its prevalence is between 7% and 10% in Western countries and almost half of all asthma patients are sensitized to one or more allergens. It is important to identify this particular group of allergic patients in order to be able to propose a targeted treatment.
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