Light-based multi-material bioprinting of vascularised adipose tissue for breast fatty tissue engineering.

Reconstructive surgery following breast cancer ablation is a surgical gold standard and of increasing importance, but current options comprising autogenous fatty tissue transfer and artificial soft tissue implants are inferior. With the advent of powerful biofabrication technologies like bioprinting, researchers for the first time have the tools to engineer life-like tissues with the ultimate goal of clinical application. In this work, we apply multi-material stereolithographic bioprinting together with a novel sacrificial biomaterial system to engineer complex fatty tissue constructs.