Publications by authors named "Joerg Nordmann"
Article Synopsis
- Toxic epidermal necrolysis (TEN) is a severe and potentially deadly skin reaction caused by common medications, featuring rapid skin detachment due to cell death, with no effective treatments currently available.
- Researchers used deep visual proteomics to analyze skin biopsies from TEN patients, identifying significant changes in proteins related to type I and II interferon signaling and activated phosphorylated STAT1, which are believed to drive the condition.
- The study found that using JAK inhibitors, like tofacitinib and baricitinib, effectively reduced skin damage in both mouse models and human patients with TEN, indicating these pathways could be targeted for potential new treatments.
Background: The diagnostic approach for beta-lactam (BL) drug hypersensitivity reactions (DHR) is based on the history, clinical signs, skin tests (ST), tests, and drug provocation tests (DPT). The aim of this study was to assess the performance of an allergy workup with ST in a real-world use.
Methods: In this cross-sectional study the rate of positive ST in subjects with suspected DHR to penicillins and cephalosporins was investigated.