CRISPRa-Mediated Upregulation of During Early Development Causes Epileptiform Activity and dCas9-Associated Toxicity.

Dravet syndrome (DS) is a monogenic epileptic encephalopathy caused by loss-of-function mutations in the voltage-gated sodium channel (VGSC) gene . DS has an age of onset within the first year of life and severe disease prognosis. In the past years, it has been shown that upregulation of endogenous can be beneficial in animal models for DS, but a complete rescue was not observed.

Thrips Resistance Screening Is Coming of Age: Leaf Position and Ontogeny Are Important Determinants of Leaf-Based Resistance in Pepper.

is a genus containing important crop species, many of which severely suffer from thrips infestation. Thrips feeding damages leaves and fruits, and often results in virus infections. Only a few insecticides are still effective against thrips, underlining the importance of finding natural resistance in crops.