Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis.

Background: The clinical relevance of parallel detection of multiple viruses by real-time polymerase chain reaction (RT-PCR) remains unclear. This study evaluated the association between the detection of multiple viruses by RT-PCR and disease severity in children with bronchiolitis.

Methods: Children less than 2 years of age with clinical symptoms of bronchiolitis were prospectively included during three winter seasons.

Cancer patients treated with sunitinib or sorafenib have sufficient antibody and cellular immune responses to warrant influenza vaccination.

Purpose: The tyrosine kinase inhibitors sorafenib and sunitinib have efficacy in several types of cancer. Recent studies indicate that these agents affect the immune system. The way it affects the immune response to influenza vaccination is unknown.

Incidence of parvovirus B19 infection among an unselected population of pregnant women in the Netherlands: A prospective study.

Objective: To evaluate seroprevalence of anti-parvovirus B19 IgG immunoglobulins and the rate of seroconversion in seronegative pregnant women.

Design: Prospective assessment of anti-parvovirus B19 IgG immunoglobulins in an unselected population of pregnant women booked for antenatal care from 1998 to 2000.

Setting: Maternity departments of an academic hospital and four affiliated teaching hospitals in the Netherlands.