Publications by authors named "Joena Bal"
Article Synopsis
- Scientists are trying to create a vaccine for HIV-1 that makes special antibodies called broadly neutralizing antibodies (bnAbs) that can fight the virus.*
- They found a way to design important boosters that help these antibodies develop stronger and better by using unique methods with special mice.*
- Their research shows that both protein and mRNA boosters can successfully help create these powerful antibodies, which is an important step toward making an effective HIV-1 vaccine.*
The CD4-binding site (CD4bs) is a conserved epitope on HIV-1 envelope (Env) that can be targeted by protective broadly neutralizing antibodies (bnAbs). HIV-1 vaccines have not elicited CD4bs bnAbs for many reasons, including the occlusion of CD4bs by glycans, expansion of appropriate naive B cells with immunogens, and selection of functional antibody mutations. Here, we demonstrate that immunization of macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural and genetic features of CD4-mimicking bnAbs.
View Article and Find Full Text PDFHelicobacter pylori maintains colonization in its human host using a limited set of taxis sensors. TlpD is a proposed energy taxis sensor of H. pylori and dominant under environmental conditions of low bacterial energy yield.
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